Principle cell organelle involved in detoxification of drugs:
Smooth endoplasmic reticulum:
Smooth-surfaced endoplasmic reticulum contains short anastomosing tubules that do not contain ribosomes hence the name smooth. They are membrane-bound cytoplasmic organelle and are commonly seen in non-protein synthesizing cells. The cell containing smooth endoplasmic reticulum (sER) exhibits eosinophilic cytoplasm or acidophilia under the light microscope. sER is well developed in cells secreting steroids like adrenal cortical cells and testicular interstitial cells. In skeletal and cardiac muscle cells they are called sarcoplasmic reticulum. sER is also more abundantly seen in the liver and there it is involved in detoxification of drugs and conjugation of other noxious substances. Apart fro detoxification sER also performs other functions such as:
1. Lipid absorption and metabolism.
2. Glycogen metabolism.
3. Membrane formation and recycling.
4. Storage of calcium ions.
Enzymes involved in the smooth endoplasmic reticulum:
Hydrolase, methylases, glucose-6-phosphatase, calcium ATPase and lipid oxidases.