The Power Course

MTAD in endodontics aids in:


1 ) Disinfect the root canal
2 ) Bleach the tooth
3 ) Activates the irrigant
4 ) All of the above



MTAD is expanded as "Mixture of tetracycline, citric acid, and detergent", used as a root canal irrigant. It is commercially available as BioPure MTAD by Dentsply, Tulsa Dental, Tulsa, OK company. It was introduced by the scientist Mahmoud Torabinejad in 2003. Commercially BioPure MTAD is available as a powder liquid system. It was observed that the cytotoxicity of MTAD was comparatively less than NaOCl, indicating the biocompatibility of MTAD. It is recommended to employ this after the initial irrigation of the canal with sodium hypochlorite. 

MTAD is capable of:

1. Disinfecting the canal and

2. Removes the inorganic portion of the smear layer. 

Composition of MTAD:

3% Doxycycline Hyclate:

It is a broad-spectrum antibiotic with bacteriostatic effect.This antibiotic does not kill bacteria but prevents the multiplication of bacteria by inhibiting the protein synthesis and reversibly binding to the 30s ribosomal subunits of microorganisms. Due to the bacteriostatic effect of doxycycline, there won't be the release of endotoxins from cell lysis into the root canal. MTAD is highly effective only when used in a full dosage that is 5 ml per root canal. 

Citric acid:

4.25% of citric acid used in the removal of the inorganic portion of the smear layer. It is a crystalline, organic acid which aids in deeper penetration of doxycycline into the dentinal tubules for performing its antibacterial action.


Polysorbate-80 also known as Tween-80 in 0.5% concentration is used as a detergent. It is a non-ionic surfactant and helps in reducing the surface tension and aiding the deeper penetration and flow of other canal irrigants like distilled water, NaOCl, EDTA. This also helps in the removal of the smear layer.

pH of MTAD:

Because of the presence of acid, its pH is 2.15. 


Disinfect the root canal

Further Reading


Last Modified : 02-Dec-2019

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