Mast cells are absent in
Mast cells are large, ovoid connective tissue cells with spherical nucleus and cytoplasm with large granules. The cell surface exhibits numerous microvilli and folds. Mast cells granules are displayed with basic dyes such as toluidine blue. These granules stain intensely, metachromatically due to its contents like heparin, sulfated proteoglycans. Mast cells contain several vasoactive and immunoreactive substances. Upon sensitization, these granules are released and they result in an immediate type of hypersensitivity reactions, allergy, and anaphylaxis.
Following are the four substances released by mast cells:
3. Slow Reacting Substance of Anaphylaxis(SRS-A)
4. An Eosinophilic Chemotactic Factor of Anaphylaxis (ECF-A)
Mast cells are numerous in the skin, mucous membranes but mast cells are absent in the brain and spinal cord.