NEET MDS

The Power Course

Disseminated intravascular coagulation, what is incorrect



Choices

1 ) Associated with septicemia
2 ) Bleeding tendency
3 ) Thrombocytosis
4 ) Increased thrombosis in small and medium-sized arteries

Explanation


Disseminated intravascular coagulation, is also called consumption coagulopathy, because there is increased thrombosis in small and medium-sized arteries, leading to the consumption of coagulation factors as well platelets. Due to the high rate of consumption, the platelet count is decreased and clotting factor deficiency happens.

This is usually a complication of severe sepsis, hematologic malignancies, severe trauma, or placental abruption.

Thrombosis of vessels, leads to the decreased blood supply, thus the patient may develop multi-organ failure.

Decreased platelet count and clotting factors lead to an increased tendency to bleed.

Laboratory  finding

Increased prothrombin time (PT), increased partial thromboplastin time(PTT). decreased fibrinogen level, thrombocytopenia, and decreased hematocrit.

Presence fibrin split products (fibrin degradation products) in the blood suggest  DIC is sensitive but not specific.

Treatment

Treat the underlying disorder

Platelets and plasma transfusion in subjects with bleeding. Platelet transfusion in patients with platelet count less than 50,000 per ml with bleeding and less than 20,000 per ml in patients even without bleeding. Similarly fresh frozen plasma, cryoprecipitate, and prothrombin complex concentrate to replenish clotting factors are to be considered.

Heparin in a patient with evidence of thrombosis and those who have no bleeding.

Activated Protein C in patients with severe sepsis


Answer

Thrombocytosis

Last Modified : 25-Dec-2019

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